Trisomie 21 is a group by Philippe and Hervé Lomprez, two brothers from Lille, France. Some people consider their music to be gothic, or French coldwave. Throughout the 1980s and '90s, T21 was signed to PIAS Records.
 
Their most popular songs are &The Last Song&, &La Fête Triste&, and &Il Se Noie&. Their most popular albums are Chapter IV, Works, Millions Lights, and The First Songs Vol 1 & 2.
 
In 2005, after 7 years of absence, Trisomie 21 released &Happy Mystery Child&.
 
In September 2007, the Belgian label Alfa Matrix (home to acts like Front 242, Leaether Strip, Anne Clark or yet Mentallo & The Fixer) announced the signing Trisomie 21.
 
Trisomie 21 are currently completing their new studio album for their new label. But first Alfa Matrix will release a special 25th anniversary release &25 anniversary& 2CD (also available as a limited 2CD boxset with t-shirt) that will not only include the &Rendez-vous en France& CD, a best-of live album from their last tour, but also a special vintage unreleased song collection and special T21 fan-goodies, the whole available on various limited editions formats.